Geophysical and archaeological work at Sais (Sa el-Hagar, Egypt) is analysed to discuss the relationships between the palaeolandscape, the evolving river and floodplain and human cultural activity at the site, where humans have lived since Neolithic times (4000 Before Common Era) until the present. The results show a close correlation with and reliance on the underlying sandhills for settlement and the way in which human activity has subsequently affected the floodplain landscape at the site.